Robert H. Cudmore, PhD
Linden Lab, Department of Neuroscience
The Johns Hopkins University
School of Medicine
My research is focused on understanding how experience, disease and aging can alter the structure and function of the brain.
I do this using time-lapse in vivo two-photon imaging in mice with genetically encoded fluorescent markers to visualize both neuronal and vascular structures. This is a powerful technique as it allows the living brain to be repeatedly imaged at a micro-meter scale over a wide range of time scales from seconds and minutes to weeks and months.
2017 - My work examining vascular and pericyte plasticity in response to exercise was published in The Journal of Cerebral Blood Flow and Metabolism (2017).
2016 - I was awarded a 4-year (2016-2020) Scientist Development Grant from the American Heart Association to examine structural and functional changes in cerebral vasculature following ischemic stroke.
2016 - Our work on serotonergic axon regeneration was published in Neuron (2016).
2015 - My work on experience dependent plasticity of surface AMPA receptor expression was published in Nature Neuroscience (2015).
To make these experiments possible, I have developed Map Manager to analyze and track 3D structures (spines, boutons and vasculature) in 3D image volume time-series. In addition, I have designed on-the-scope instrumentation including a spatial image acquisition canvas and a motorized treadmill with synchronized video to be used during awake in vivo two-photon imaging.
|Dept. of Neuroscience, Linden Lab||Johns Hopkins Medicine||© 2008-2018|