Robert Cudmore

Robert H Cudmore Robert H. Cudmore, PhD
Research Associate

Linden Lab, Department of Neuroscience
The Johns Hopkins University
School of Medicine

Email:

Research Interests

My research is focused on understanding how experience, disease and aging can alter the structure and function of the brain.

I do this using time-lapse in vivo two-photon imaging in mice with genetically encoded fluorescent markers to visualize both neuronal and vascular structures. This is a powerful technique as it allows the living brain to be repeatedly imaged at a micro-meter scale over a wide range of time scales from seconds and minutes to weeks and months.

Please see the images page for an overview.

News

[2017] My work examining vascular and pericyte plasticity in response to exercise was published in The Journal of Cerebral Blood Flow and Metabolism (2017).

[2016] I was awarded a 4-year (2016-2020) Scientist Development Grant from the American Heart Association to examine structural and functional changes in cerebral vasculature following a stroke.

[2016] Our work on serotonergic axon regeneration was published in Neuron (2016).

[2015] My work on experience dependent plasticity of surface AMPA receptor expression was published in
Nature Neuroscience (2015).

Software

To make these experiments possible, I am developing software to analyze and track 3D structures (spines, boutons and vasculature) in 3D image volume time-series.

There are two main branches of this software, one for neurons and the other for vasculature.

Another important dimension to this research is 'on the scope' instrumentation. For this I have developed a complete hardware/software solution for a motorized treadmill with synchronized video to be used during awake in vivo two-photon imaging.

Dept. of Neuroscience, Linden Lab Johns Hopkins Medicine © 2008-2016